Tuesday 6th of October at 11:00h, Ángel P. Diz, associated profesor at The Universidade de Vigo and senior researcher on the Population Genetics and Cytogenetics Group (XB2, CIM-UVigo), will present the conference Biparental inheritance of mtDNA in humans: what can research on marine mussels tell us?.
A controversial work has recently been published providing evidence of biparental inheritance of mitochondrial DNA in humans defying the general rule of strict maternal inheritance in the animal kingdom. Today more than 100 bivalve species, marine mussels (Mytilus spp.) between them, follow an unusual mode of mitochondrial DNA inheritance named Doubly Uniparental Inheritance (DUI), where inheritance of both highly diverged maternal and paternal mitogenomes is the general rule rather than the exception.
These exceptions could be useful to investigate molecular mechanisms underlying paternal mtDNA transmission to offspring. Although the molecular mechanisms underlying DUI have not been discovered yet, there have been some interesting advances in this direction with proteomic results contributing also to this quest.
The Population Genetics and Cytogenetics Group will contribuit to accelerate research in DUI through High-performance genomic and proteomic technology, thanks to the project “Mitogenomics and mitoproteomics of marine mussels with doubly uniparental inheritance of mitochondria DNA and different genetic background” (MYTOLINES), funded by the Ministerio de Ciencia e Innovación (Spanish Government). The project, directed by Ángel E. Pérez and Paloma Morán, aims to know the potential involvement of selected mitochondrial proteins in several species of marine mussels in the Doubly Uniparental Inheritance molecular mechanism, sex determination and the influence of DUI in reproductive isolation . The results could be useful in understanding exceptional reported cases in humans.
During his conference, the speaker will present us the principal conclusions of the controverted study in humans and the relationship with the actual knowledge of the mussel mtDNA Doubly Uniparental Inheritance. Finally, he will present a brief description of the general objectives af the MYTOLINES Project, already kicked off at ECIMAT facilities.
The conference will be held virtually, being live streaming through the Remote Campus of the University of Vigo. To Access please follow the instructions bellow:_
- Press the virtual room URL https://campusremotouvigo.gal/access/public/meeting/928607699
- Access as student with the next password: 6rAsLWyz
- Select the microphone access mode and silent it until the question time
The conference will be permanetly available at CIM and UVigoTV websites.
Vídeos
- Presentation of Ángel Pérez Diz Alba Hernández Otero - CIM
- Biparental inheritance of mtDNA in humans: what can research on marine mussels tell us? Ángel Pérez Diz (Population Genetics and Cytogenetics Group, CIM-UVigo)
- Question time Ángel Pérez Diz (Population Genetics and Cytogenetics Group, CIM-UVigo)